PerFem Forte™ - References
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Indication: menopausal syndrome, hormonal imbalance, cardio-vascular and nervous system support, prevention of osteoporosis and cancer of the female reproductive organs.
Actions: normalizes the balance of female hormones, relieves symptoms of menopause, antioxidant defense, prevents aging, promotes healthy nervous and cardiovascular systems, increases endurance and work capacity, has a beneficial impact on appearance.
Ingredients (per 1 packet):
Vitamin E (as d-alpha-tocopheryl succinate) - 15 IU, Thiamin (as thiamin mononitrate) - 1 mg, Riboflavin - 1 mg, Niacin (as niacinamide) - 10 mg, Vitamin B6 (as pyridoxine HCl) - 3 mg, Folate (as metafolin) - 200 mcg, Vitamin B12 (as cyanocobalamin) - 3 mcg, Selenium (as selenium + GMP™) - 35 mcg, Fermented (aglycone) VDF Isoflavones™ (from organic GMO-Free soybean extract and GMO-Free red clover extract (aerial parts))- 25.5 mg, Black cohosh (Cimicifuga foetida) (12:1) root extract [(8% triterpene glycosides (as 27-deoxyactein)] (equivalent to 150 mg of crude herb) - 12.5 mg.
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PerFem Forte™ - References:
1. Perloff WH. Treatment of the menopause. Am J Obstet Gynecol 1949;58:684-94.
2. Grant JE, Veldee MS, Buchwald D. Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome. J Am Diet Assoc 1996;96:383-6.
3. Brown WV. Niacin for lipid disorders. Postgrad Med 1995;98:185–93 [review].
4. Guyton JR. Effect of niacin on atherosclerotic cardiovascular disease. Am J Cardiol 1998;82(12A):18U–23U [review].
5. Bottiglieri T, Reynolds EH, Laundy M. Folate in CSF and age. J Neurol Neurosurg Psychiatry 2000; 69: 562
6. Homocysteine Lowering Trialists‘ Collaboration: Lowering blood homocysteine with folic acid based supplements: metaanalysis of randomised trials. BMJ 1998;316:894-8.
7. Wu K, Helzlsouer KJ, Comstock GW, et al. A prospective study on folate, B12, and pyridoxal 5’-phosphate (B6) and breast cancer. Cancer Epidemiol Biomarkers Prev 1999;8:209-17.
8. Peretz A, Néve J, Desmedt J, et al. Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast. Am J Clin Nutr 1991;53:1323-8.
9. Clark LC, Combs GF, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. JAMA 1996;276:1957-63. Published erratum appears in JAMA 1997;277:1520.
10. Van de Weijer PHM, Barentsen R. Isoflavones from red clover (Promensil®) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002;42:187-93.
11. Nestel PJ, Pomeroy S, Kay S, et al. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women.
12. Helena J. Teede; Barry P. McGrath; Lakmini DeSilva; Marja Cehun; Andriana Fassoulakis; Paul J. Nestel. A Placebo-Controlled Study in Men and Postmenopausal Women. Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:1066.
13. J Clin Endocrinol Metab 1999;84:895-8. ACOG Practice Bulletin. Clinical Management Guidelines for Obstetrician-Gynecologists. Use of botanicals for management of menopausal symptoms. Obstet Gynecol 2001;97:suppl 1-11.
14. International Journal of Cancer, April 1, 2007.
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PerFem Forte™ 
